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Procaine benzylpenicillin+Neomycin Sulphate 20%:10%
Procaine benzylpenicillin+Neomycin Sulphate 20%:10%
Procaine benzylpenicillin+Neomycin Sulphate 20%:10%
(Item No.: LI019)

COMPOSITION:
Each ml contains:
Procaine benzylpenicillin.............................. 200 mg (200,000 i.u.)
Neomycin base(as the sulphate).................100 mg
DESCRIPTION:
It is an off-white suspension of procaine penicillin in a solution of neomycin sulphate.
INDICATIONS:
Penicillin is active against some Gram-negative and most Gram-positive bacteria. Neomycin is a broad spectrum antibiotic active against a number of Gram-positive and Gram-negative bacteria.
For the treatment of infectious diseases in horses, sheep, pigs, dogs and cats caused by bacteria sensitive to the combination. The combination shows a broad spectrum of activity.
In vitro activity has been demonstrated against all tested isolates of Erysipelas rhusiopathiae, Streptococcus spp. and Actinomyces pyogenes and the majority of tested isolates of Pasteurella, Salmonella, Klebsiella and Staphylococcus spp.
DOSAGE AND ADMINISTRATION:
The following table is only intended as a guide and is calculated at a dosage rate of 5 mg/kg neomycin base (5 ml/100 kg) for large animals and 10 mg/kg (1 ml/10 kg) in small animals as representing the maximum dose.
Species Weight Maximum dose
Horse 500 kg 25.0 ml
Sheep 50 kg  2.5 ml 
Pig 50 kg  2.5 ml 
Dog 10 kg  1.0 ml 
Cat 5 kg   0.5 ml 
The dose should be repeated at 24 hour intervals as required to a maximum of three doses.
Administration should be by deep intramuscular injection in all species. Observe aseptic precautions.
A suitably calibrated syringe should be used to ensure accurate injection of small volumes.
CONTRAINDICATIONS,WARNINGS,ETC.
Overdosage with neomycin parenterally can cause renal damage and deafness but this is unlikely at normal therapeutic dosage levels. Care should be taken in young animals, particularly puppies, kittens and piglets, to ensure accurate computation of the dose.
Courses of this product should be restricted to a period of three days.
Occasionally in sucking and fattening pigs, administration of this product may cause a transient pyrexia, vomiting, shivering, listlessness and incoordination.
Additionally in pregnant sows and gilts, a vulval discharge which could be associated with abortion has been reported. The balance of risks should be considered carefully prior to use.
Local reaction (swelling) may occur at the injection site in horses for up to a week after administration.
Doses exceeding 15 ml should be divided between two injection sites.
Not to be used in animals known to be hypersensitive to Beta-lactam antibiotics.
WITHDRAWAL TIMES:
Pigs and sheep should not be slaughtered for human consumption during treatment. Pigs may only be slaughtered for human consumption from 60 days after the last treatment; sheep from 70 days after the last treatment.
Not to be used in sheep producing milk for human consumption.
Not to be used in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human consumption under national horse passport legislation.
USER WARNINGS
Care should be taken to avoid accidental self-injection.
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may cause cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.
1.Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
2.Handle this product with great care to avoid exposure, taking all recommended precautions.
3.If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes, or difficulty with breathing are more serious symptoms and require urgent medical attention.
Wash hands after use.
For animal treatment only. Keep out of the reach and sight of children.
PHARMACEUTICAL PRECAUTIONS:
Store between +2°C and +8°C. Protect from light.
Keep container in outer carton.
Shake container before use. Following withdrawal of the first dose, use the product within 28 days. When the container is broached for the first time, the date on which any product remaining in the container should be discarded should be calculated. A statement of the in-use shelf life of the product is given on the packaging insert. This discard date should be written in the space provided on the label.
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.